The role of PCSK9 in the pathogenesis of non-alcoholic fatty liver disease

The role of PCSK9 in the pathogenesis of non-alcoholic fatty liver disease

Statin treatment exhibits a beneficial effect in patients of cardiovascular diseases (CVD) and non-alcoholic fatty liver disease (NAFLD). Statins are common treatments for such conditions.

The role of pro-protein convertase subtilisin kexin type-9 (PCSK9) in the pathogenesis of NAFLD is summarized in this review. The authors also review the effects of the new hypolipidaemic drugs—PCSK9 inhibitors—on NAFLD. Increments in high intrahepatic or circulating PCSK9 levels in muscle and liver lipid storage was indicated by research data. The increment was also observed in adipose energy storage and hepatic fatty acids, as well as triglycerides storage and secretion, thus contributing to the pathogenesis of NAFLD.

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